After cloning a system disk, the new SSD sometimes shows up with the wrong drive letter. Windows may boot from the SSD but label it D or E, or it may refuse to boot at all because the boot record still points to the old letter. This happens because drive letters are stored in the registry, not on the disk itself.
This guide explains why the letter changes, how to restore C to the cloned SSD, and how to repair the boot so Windows starts from the right drive.
The fix is to give the SSD the C letter while the old drive is disconnected, or to change the letter in Windows Recovery if the system will not boot.

If C is already taken by another volume, change that volume to another letter first, then assign C to the SSD. Restart after the change.

If Windows still will not boot after the letter fix, the BCD still points to the wrong volume. Rebuilding it from Recovery fixes the path without reinstalling.
If the letter problem keeps coming back, the clone tool may have copied a broken layout. Re-clone with a tool that rebuilds the boot records for the target drive.
Watch the video tutorial below to clone the drive step by step with Qiling Disk Master.
Step 1. Open Qiling Disk Master, choose Clone, and then select Disk Clone.

Step 2. Select the source disk and click Next.

Step 3. Select the destination SSD and confirm that its data will be replaced.

Step 4. Choose the clone mode and confirm the system partition gets the C letter on the target.

Step 5. Click Proceed, wait for the copy to finish, then shut the machine down before you remove any cable.

If the letter reverts after a restart, the registry MountedDevices key is stale. Boot into Safe Mode and reassign the letter there.
The old drive was still connected and kept the C letter. Disconnect the old drive and assign C to the SSD in Disk Management.
Not safely. Change it from Recovery or by booting with the old drive disconnected.
Most programs break if they were installed on a letter that changes. Assign the original letter to avoid this.
The partition may not be marked active or the file system is not recognized. Check Disk Management and assign a letter manually.
Boot from a Windows USB, open Command Prompt, and run bootrec /rebuildbcd to rebuild the boot records.
Changing drive letters and rebuilding the BCD can make the system unbootable. Back up first so you can restore if the repair fails.
Watch the video tutorial below to back up Windows and restore it if the clone fails.
Step 1. Open Qiling Disk Master and select System Backup to include the boot partitions.

Step 2. Save the image to a drive other than the target disk and start the backup.

Step 3. Click Proceed to start the system backup and wait patiently until it finishes. You can also tick Shut down the computer when the operation is completed to power off automatically.

Step 4. If the SSD still shows the wrong letter, restore the image and reassign the letter or rebuild the BCD from Windows Recovery.

A wrong drive letter after cloning comes from the registry, not from the disk. Disconnect the old drive, assign C to the SSD in Disk Management, and rebuild the BCD if Windows will not boot. If the problem repeats, re-clone with a tool that rebuilds the boot records for the target drive.
For more on boot issues after cloning, see Cloned Drive Won't Boot? Fix It, How to Clone the Windows 11 System Reserved Partition, Clone an MBR Disk to a GPT SSD, and Clone a GPT Disk to an MBR Disk.