Two drives of the same capacity can still disagree about their sector size. One reports 512 bytes per sector and the other reports 4096, and a clone that ignores the difference may copy data into the wrong offsets.
This guide explains what the sector size actually controls, how to read it, and which clone settings keep the copy bootable when the source and target differ.
The three common cases are 512n, 512e, and 4Kn. Only 4Kn reports a true 4096-byte logical sector, and that is the case where a naive clone most often breaks.

If the source is 512e and the target is 4Kn, the copy needs sector conversion or a partition rebuild. If both are 512e, a raw clone is safe even when the media underneath is 4K.

A raw copy of a 512e disk onto a 4Kn disk without conversion produces a drive that looks correct in Windows but cannot boot. The firmware reads a boot record that is no longer where it expects.
Qiling Disk Master copies the disk layout as Windows sees it and warns when the target cannot hold the source partitions. Download it before you attach the new drive.
Step 1. Open Qiling Disk Master, choose Clone, and then select Disk Clone.

Step 2. Select the source disk and click Next.

Step 3. Select the target disk and confirm that its data will be replaced.

Step 4. Review the partition offsets, keep the boot volumes, and align any resized partition to 4K.

Step 5. Click Proceed, wait for the copy to finish, then shut the PC down before you remove the adapter.

If the copy will not start, rebuild the boot record from recovery media before you touch the partitions. The steps in Cloned Drive Wont Boot Fix cover both UEFI and legacy firmware.
Not with a plain raw copy. The target needs sector conversion or rebuilt partitions, or it will not boot.
Use diskpart or the disk properties page. The logical sector size is what the clone follows.
Yes. It emulates 512-byte sectors, so alignment still matters for performance but not for boot code offsets.
It may boot and work, but every write touches two sectors, so the drive feels slower than it should.
Only when the layout is unusual or damaged. For a normal healthy disk, a standard disk clone keeps the offsets.
Before you change drives, create a full image of the source. Qiling Disk Master can write an image that you restore if the conversion goes wrong.
Step 1. Open Qiling Disk Master and select System Backup to include every partition of the source disk.

Step 2. Save the image to a drive other than the target disk and start the backup.

Step 3. Click Proceed to start the system backup and wait patiently until it finishes. You can also tick Shut down the computer when the operation is completed to power off automatically.

Step 4. If the new disk will not start, restore the image to the original drive and repeat the clone.

Sector size is a compatibility question, not a capacity question. Read the logical sector size of both drives, keep the original partition offsets for a raw copy, and use 4K alignment whenever you rebuild a partition. A 512e to 4Kn move needs conversion rather than a plain clone. Back up first, verify alignment after the copy, and rebuild the boot record if the firmware cannot find it.
For more on disk layout, see 4K Alignment When Cloning an SSD, How to Clone an MBR Disk to a GPT SSD, How to Clone a Hard Drive with Bad Sectors, and Cloned Drive Wont Boot Fix.