An M.2 slot is valuable hardware. Moving Windows onto a SATA SSD frees that slot for a faster NVMe drive or for a build that needs the bandwidth elsewhere.
This guide explains the adapter and capacity checks, the boot settings that keep the copy startable, and the clone steps with Qiling Disk Master.
The switch costs speed. A SATA SSD tops out around 550 MB/s, while the M.2 drive may have been several times faster.

A SATA SSD needs no NVMe driver, but the firmware must still see it as a boot candidate. Confirm that in the BIOS device list before the copy.

If the plan is to reuse the M.2 slot for a data drive, add that drive only after the SATA system boots. Two Windows entries at once cause confusion.
Qiling Disk Master copies the full disk, including the EFI and recovery partitions, from the M.2 drive to the SATA SSD.
Step 1. Open Qiling Disk Master, choose Clone, and then select Disk Clone.

Step 2. Select the M.2 drive as the source and click Next.

Step 3. Select the SATA SSD in the adapter as the destination and confirm that its data will be replaced.

Step 4. Review the partitions, keep the EFI and recovery volumes, and tick Optimize for SSD.

Step 5. Click Proceed, wait for the copy to finish, then shut down and install the SATA SSD in the bay.

If the firmware ignores the SATA disk, check the port, the cable, and the boot mode. Cloned Drive Wont Boot Fix explains the boot entry repair.
Yes when the whole disk is copied with its EFI or system reserved partition and the boot entry points to it.
Sequential speed is lower, but everyday app loading stays responsive because random access is still fast.
Yes. Use a USB 3.0 SATA adapter, then install the drive in a SATA bay before the first boot.
No. The SATA controller uses the standard AHCI driver that Windows already includes.
Yes after the SATA copy boots. Format it as a data volume instead of leaving a second Windows install.
Before changing drives or partitions, create a full system backup. Qiling Disk Master creates an image you can restore from.
Step 1. Open Qiling Disk Master and select System Backup to include Windows and the boot partitions.

Step 2. Save the image to a drive other than the target disk and start the backup.

Step 3. Click Proceed to start the system backup and wait patiently until it finishes. You can also tick Shut down the computer when the operation is completed to power off automatically.

Step 4. If the copy will not start, restore the image to a spare drive and boot from it.

An M.2 to SATA move is a straight disk clone as long as the adapter and boot mode are right. Confirm the SATA port, keep the partition style, suspend BitLocker, and copy the whole disk so the boot partitions come along. After the swap, enable AHCI, set the SATA entry first, confirm TRIM, and remove the M.2 drive before you reuse its slot.
For more on drive swaps, see How to Clone a 2.5-inch SSD to M.2, 4K Alignment When Cloning an SSD, Cloned Drive Wont Boot Fix, and How Long Does a Disk Clone Take.